

22-night South America & Antarctica Cruise
Aboard
Oosterdam
From
San Antonio, Santiago, Chile
3 Sailings
Jan 9, 2026 - Jan 8, 2028
Published prices from
$6,079
per person*
taxes & fees included
Santiago is a dynamic capital city nestled between the Andes and the Pacific, where urban energy meets natural beauty.

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Aboard
Oosterdam
From
San Antonio, Santiago, Chile
3 Sailings
Jan 9, 2026 - Jan 8, 2028
Published prices from
per person*
taxes & fees included


Aboard
Seabourn Pursuit
From
San Antonio, Santiago, Chile
2 Sailings
Apr 2, 2026 - Apr 7, 2027
Published prices from
per person*
taxes & fees included


Aboard
Oosterdam
From
San Antonio, Santiago, Chile
2 Sailings
Mar 24, 2027 - Mar 21, 2028
Published prices from
per person*
taxes & fees included


Aboard
Carnival Firenze
From
San Antonio, Santiago, Chile
1 Sailing
Jan 19, 2027
Published prices from
per person*
taxes & fees included


Aboard
Majestic Princess
From
San Antonio, Santiago, Chile
1 Sailing
Dec 22, 2026


Aboard
Oosterdam
From
San Antonio, Santiago, Chile
2 Sailings
Dec 4, 2026 - Dec 2, 2027
Published prices from
per person*
taxes & fees included


Aboard
Oosterdam
From
San Antonio, Santiago, Chile
2 Sailings
Feb 23, 2027 - Feb 21, 2028
Published prices from
per person*
taxes & fees included


Aboard
Azamara Journey
From
San Antonio, Santiago, Chile
1 Sailing
Mar 10, 2027
Published prices from
per person*
taxes & fees included


Aboard
Seabourn Pursuit
From
San Antonio, Santiago, Chile
1 Sailing
Nov 4, 2026
Published prices from
per person*
taxes & fees included


Aboard
Seabourn Pursuit
From
San Antonio, Santiago, Chile
1 Sailing
Apr 2, 2026

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Overview
Chile’s largest city offers a striking setting—surrounded by mountains and filled with cultural, culinary, and architectural highlights. In neighborhoods like Bellavista and Lastarria, you’ll find colorful street art, buzzing cafés, and some of the city's best food and nightlife. The city’s blend of colonial buildings and sleek modern towers reflects its evolving spirit and deep-rooted history.
Must-see attractions include the hilltop views from Cerro San Cristóbal, the historic Plaza de Armas, and the moving exhibits at the Museum of Memory and Human Rights. Wine lovers will also enjoy day trips to nearby vineyards in the Maipo Valley, known for producing excellent reds.
Santiago’s central location makes it a great base for exploring more of Chile—from the coastal charm of Valparaíso to the rugged Andes. Whether you are soaking in city life or using it as a springboard for adventure, Santiago offers a compelling mix of culture, scenery, and South American warmth.

Start your visit by taking in the views of San Antonio's bustling port, which is one of the most important on the Pacific coast of Chile. The port serves as a hub for both freight and passenger ships, and it’s interesting to watch the activity and scale of the operations. Although the port area itself is more industrial, there are opportunities to learn about its importance to Chile's economy and maritime industry.
Tip: If you are interested in the maritime history and trade of the region, check out nearby museums or take a walking tour to learn more about the port’s role in the Chilean economy.

San Antonio is just a short drive from some beautiful beaches along the Aconcagua Coast. If you love the sea and beach activities, spend some time at one of the nearby beach towns like Playa San Juan de la Costa or El Quisco. These coastal areas are perfect for relaxing by the sea, swimming, or enjoying fresh seafood at local beachside restaurants.
Tip: Head to Playa de Canelo for a quieter, scenic beach escape with clear waters and a peaceful environment.

For a truly memorable experience, consider a visit to Isla Negra, which is about 30 minutes from San Antonio. Here, you’ll find the famous home of Pablo Neruda, Chile’s beloved poet and Nobel Laureate. La Casa de Isla Negra is now a museum, offering a glimpse into Neruda’s life and creative genius. The museum houses a collection of his personal belongings, artwork, and stunning views of the Pacific Ocean.
Tip: Be sure to stroll through the gardens surrounding the house and enjoy the panoramic views of the sea that inspired many of Neruda’s poems.

Chile is renowned for its wine, and the Casablanca Valley, located about 45 minutes from San Antonio, is one of the country’s premier wine-producing regions. A visit to the Casablanca Valley offers a perfect opportunity for wine lovers to tour some of Chile’s renowned vineyards and wineries. You can learn about the wine-making process, sample delicious wines, and enjoy the stunning vineyard landscapes.
Tip: Make a reservation at one of the wineries for a wine-tasting experience and a chance to try Chile’s famous Sauvignon Blanc and Pinot Noir wines.

While San Antonio itself is a port town, it offers some charm for visitors who are curious about the local culture and lifestyle. Wander through the town’s plazas and markets, where you can find fresh produce, handmade crafts, and local goods. If you’re in the mood for a traditional Chilean meal, there are plenty of restaurants serving empanadas, fresh seafood, and local specialties.
Tip: If you are visiting during the weekend, the town hosts lively markets where you can buy local artisan products and souvenirs.

For a different perspective on the region, consider booking a boat tour of the San Antonio Bay. These tours offer great views of the coastline, nearby islands, and the port. You can enjoy the beauty of the area from the water and even spot local wildlife, such as sea lions, dolphins, and various seabirds.
Tip: Check with local tour operators about boat trips to nearby islands like Isla de los Pajaros (Island of Birds), a protected area home to many seabirds.

A short drive from San Antonio, El Quisco is a coastal town known for its relaxed vibe and beautiful beaches. It’s a great spot to spend a leisurely afternoon, enjoying a peaceful walk along the shore or dining at one of the local seafood restaurants. El Quisco is also home to Pablo Neruda’s former summer home, adding a touch of literary history to your visit.
Tip: Enjoy a delicious seafood dish at one of the local beachfront restaurants, where you can try machas (Chilean clams) or ceviche.

If you are keen on experiencing the local agricultural scene, head to the San Antonio Agricultural Market. This market is a hub for fresh fruits, vegetables, and local produce. It’s a great place to pick up some fresh produce or local food products to take home as souvenirs. You can also interact with local vendors and learn about the region’s farming culture.
Tip: Look for Chilean specialties like avocados, fresh berries, and chile picante (spicy chili) to bring a taste of Chile back with you.

For stunning panoramic views, head to the Algarrobo Cliffs, located a short drive from San Antonio. This area offers breathtaking views of the Pacific Ocean and the surrounding coastline. it is a perfect spot to enjoy the natural beauty of the region, take photos, or simply relax while watching the waves crash against the cliffs.
Tip: Bring a camera for some excellent photo opportunities, especially during sunset when the colors over the ocean are particularly beautiful.

San Antonio has a burgeoning local art scene, with galleries and workshops showcasing the work of regional artists. Check out the town’s art galleries or artisan workshops to see unique pieces of ceramics, paintings, and handmade crafts. This is a great way to learn about the culture and artistic traditions of the region while supporting local creators.
Tip: Look for souvenirs like hand-painted pottery or woven textiles, which make for unique and meaningful gifts to take home.