22-night South America & Antarctica Cruise From San Antonio, Santiago, Chile

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Two young elephant seals playing in a small pool of water on a beach covered in seaweed, with icebergs and a dramatic cloudy sky in the background of Drake Passage.
Holland America's Oosterdam sailing in Alaska.
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Sailing Jan 10, 2027

Your 22-night South America Cruise at a Glance

Sailings aboard Oosterdam depart from San Antonio, Santiago, Chile with 16 stops in ports-of-call including Puerto Montt, Port Stanley, and Punta Arenas. The Cruise Web can help you find the best deals and stateroom prices on the next sailing January 10, 2027.

Santiago is a dynamic capital city nestled between the Andes and the Pacific, where urban energy meets natural beauty. Before you depart San Antonio, Santiago, Chile, we can help you plan travel and accommodations for your South America cruise.

Destination

South America

Stops on your South America voyage will include Canal Sarmiento on day 6 and Punta Arenas on day 7. We can help you with excursions and making the most of any itinerary.

Cruise Ship

Oosterdam

Oosterdam, built in 2003 and refurbished in 2019, carries 1,964 passengers with a crew of 817. Ask us about dining options like Canaletto and entertainment like Cantare!

Amazing food and superb service make Holland America one of the longest running cruise lines. We can help you maximize deals on South America cruises aboard Oosterdam or 10 of Holland America’s other ships.