South American River Cruise Deals

Aerial view of a winding river flowing through the lush Amazon rainforest in Brazil, showcasing South America's natural beauty.

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An aerial view of the historic walled city of Cartagena, Colombia, showing the vibrant architecture of churches and colonial buildings, with the ocean in the background under a soft morning light.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-night Wonders Of Colombia with 3-nights in Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Cartagena, Colombia

Modern Panama City skyline with skyscrapers.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 Nights in Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Cartagena, Colombia

A close-up of a row of colonial buildings with vibrant, colorful facades in San Basilio de Palenque, Colombia, featuring brightly painted balconies and red-tiled rooftops.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia Cruise

Aboard

AmaMagdalena

From

Cartagena, Colombia

Aerial view of Medellín River and city with mountains in Colombia.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Medellín, Colombia

Published prices from

$4,764

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Medellín, Colombia

Published prices from

$6,762

per person*

taxes & fees included

Modern Panama City skyline with skyscrapers.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-Night Magic of Colombia With 3 Nights In Medellín Pre Cruise And 3 Nights In Panama City Post Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

Published prices from

$6,916

per person*

taxes & fees included

A beautiful colonial-era church in Mompox, Colombia, with its vibrant yellow facade, ornate bell tower, and bright red dome standing out against a clear blue sky.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-night Magic Of Colombia With 3-nights Medellín Pre Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

Published prices from

$4,741

per person*

taxes & fees included

Modern Panama City skyline with skyscrapers.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia with 3 Nights Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Barranquilla, Colombia

Colorful colonial balconies in Cartagena.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia Cruise

Aboard

AmaMelodia

From

Barranquilla, Colombia

Published prices from

$3,339

per person*

taxes & fees included

An aerial view of a vibrant yellow colonial church with a red-tiled roof and bell tower, the main landmark of the historic town of Santa Bárbara de Pinto in Colombia.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia Cruise

Aboard

AmaMagdalena

From

Barranquilla, Colombia

Published prices from

$3,049

per person*

taxes & fees included

A beautiful colonial-era church in Mompox, Colombia, with its vibrant yellow facade, ornate bell tower, and bright red dome standing out against a clear blue sky.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-night Magic Of Colombia With 3-nights Panama Post Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Barranquilla, Colombia

Barranquilla city skyline at sunset.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise and 3 Nights in Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

A close-up of a row of colonial buildings with vibrant, colorful facades in San Basilio de Palenque, Colombia, featuring brightly painted balconies and red-tiled rooftops.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

Aerial view of Magangué, Colombia, a densely built town with colorful roofs, bordered by a murky river/lake and lush green land, under an overcast sky.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 2 Nights Cartagena Pre-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Cartagena, Colombia

Colorful colonial balconies in Cartagena.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia with 3 nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

Published prices from

$7,462

per person*

taxes & fees included

Aerial view of Medellín River and city with mountains in Colombia.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise Cruise/Land Package

Aboard

AmaMagdalena

From

Medellín, Colombia

Published prices from

$5,464

per person*

taxes & fees included

An aerial view of the historic walled city of Cartagena, Colombia, showing the vibrant architecture of churches and colonial buildings, with the ocean in the background under a soft morning light.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 Nights in Medellin and 2 Nights in Cartagena Pre-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Medellín, Colombia

Published prices from

$5,699

per person*

taxes & fees included

A panoramic shot of a wide, calm river flowing through a lush, green landscape under a bright blue sky with white clouds in Nueva Venecia, Colombia.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 nights in Medellin, 2 nights in Cartagena Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Medellín, Colombia

Published prices from

$8,562

per person*

taxes & fees included

An aerial view of a vibrant yellow colonial church with a red-tiled roof and bell tower, the main landmark of the historic town of Santa Bárbara de Pinto in Colombia.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 2 Nights in Cartagena Pre-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Cartagena, Colombia

Published prices from

$5,139

per person*

taxes & fees included

Aerial view of Magangué, Colombia, a densely built town with colorful roofs, bordered by a murky river/lake and lush green land, under an overcast sky.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia Cruise

Aboard

AmaMelodia

From

Cartagena, Colombia

Published prices from

$4,239

per person*

taxes & fees included

Aerial view of Magangué, Colombia, a densely built town with colorful roofs, bordered by a murky river/lake and lush green land, under an overcast sky.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 2 more offers
AmaWaterways

7-night Wonders of Colombia with 3 Nights in Panama City Post-Cruise Cruise/Land Package

Aboard

AmaMelodia

From

Cartagena, Colombia

Colorful colonial balconies in Cartagena.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-night Magic Of Colombia Cruise

Aboard

AmaMagdalena

From

Barranquilla, Colombia

Published prices from

$3,549

per person*

taxes & fees included

A large group of sea lions sunbathing on a rocky outcrop in the sea, a common sight at the Paracas National Reserve in Peru.
FREE Guided Tours, Drinks, Fine Dining, Wi-Fi & More*
Avalon Waterways

19-night From The Inca Empire To The Peruvian Amazon With The Nazca Lines & Galápagos Cruise/Land Package

Aboard

Delfin III

From

Lima, Peru

A clear view of the mysterious Candelabra of the Andes geoglyph, a pre-Inca etching carved into a sandy hillside, overlooking the Pacific Ocean near Pisco, Peru.
FREE Guided Tours, Drinks, Fine Dining, Wi-Fi & More*
Avalon Waterways

12-night From The Inca Empire To The Peruvian Amazon With The Nazca Lines Cruise/Land Package

Aboard

Delfin III

From

Lima, Peru

Published prices from

$8,258

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.
FREE Excursions, Specialty Dining, Wi-Fi & More*+ 3 more offers
AmaWaterways

7-night Wonders Of Colombia Cruise

Aboard

AmaMagdalena

From

Cartagena, Colombia

Published prices from

$3,149

per person*

taxes & fees included

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.

More to Explore

Cruise Lines

MSC Cruises

Holland America Line

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AmaWaterways

Destinations

Nile River

Asian River

Moselle River

Australia/New Zealand

Transpacific

Ports

Kiriwina Island, Trobriand Islands, Papua New Guinea

Puerto Montt, Chile

Dampier Archipelago, Australia

Apra, Guam

Ashmore Reef, Australia

Cruise Ships

S.S. São Gabriel

AmaMaya

Grandeur of the Seas

Celebrity Solstice

Carnival Radiance