21 nights West Caribbean From Miami, Florida

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Miami skyline at dusk, showcasing vibrant colors and reflections shimmering in the water below.
MSC Poesia cruise ship exterior.
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MSC Poesia cruise ship exterior.

Departing

Visiting

Miami, Florida


10 Ports of Call

Sailing Oct 22, 2026 - Mar 16, 2028

from $2,001 per person* taxes and fees included

Your 21-night South America Cruise at a Glance

Sailings aboard MSC Poesia depart from Miami, Florida with 10 stops in ports-of-call including George Town, Ocho Rios, and Cabo Rojo. The Cruise Web can help you find the best deals and stateroom prices on any of the 23 upcoming sailings in 2026, 2027 and 2028.

Departure Port

Miami, Florida

Miami is a sun-soaked city that blends beach life, global flavors, and bold style into one vibrant, nonstop experience. Before you depart Miami, Florida, we can help you plan travel and accommodations for your South America cruise.

Destination

South America

Stops on your South America voyage will include Ocho Rios on day 3 and Willemstad, Curacao on day 15. We can help you with excursions and making the most of any itinerary.

Cruise Ship

MSC Poesia

MSC Poesia, built in 2008 and refurbished in 2023, carries 2,550 passengers with a crew of 1,039.

Cruise Line

MSC Cruises

Enjoy Italian luxury and eco-conscious vacationing with MSC Cruises. We can help you maximize deals on South America cruises aboard MSC Poesia or 23 of MSC’s other ships.