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Expert guidance with no booking fees!
MSC Cruises Military Discount: up to 10% OFF*
MSC Cruises South America cruises from $219*
MSC Cruises Holiday cruises from $128*
See some of the most incredible landscapes in the world, along with wildlife and cultures that will leave you in awe with an MSC Cruises South America cruise. While at port in Buenos Aires, you can sample the legendary nightlife of the city, or spend a relaxing night shopping at the local market. In Rio de Janeiro, you can delve deep into the Brazilian rainforest by jeep, taking a wild expedition between the towering trees. Snorkel in the beautiful Pacific waters, or find local cuisine that will truly satisfy. Make some memories worth passing on—cruise to South America with MSC Cruises.
View MSC Cruises to South America
Awe inspiring views, hip shaking dances and delightful culture are what to expect in South America. When cruising to South America with MSC Cruises, you can see Rio from the top of Sugar Loaf Mountain, learn about the roots of Pope Francis in Buenos Aires and visit vineyards in Uruguay.
Learn more about the different departure ports for a South America cruise with MSC Cruises. Your MSC Cruises South America cruise could embark from any of the following cities:
Salvador is the largest city in the Northeast Region, situated on a peninsula that extensively shields the Bay of All Saints from the Atlantic Ocean.
Buenos Aires is a charming European style city with the perfect combination of new world characteristics mixed with old world history and culture.
The city sits right on the Atlantic Ocean coast at the mouth of the beautiful Rio Itajai, or the Itajai-Acu River.
Maceio is a Brazilian city that is named for natural, spontaneous flows of water that spurts from the soil. A beautiful city in Brazil, a must-see.
The cruise port of Montevideo, Uruguay is a multifaceted destination with a vibrant culture, and a well-known hub for technological advancement.
Paranagua is a historic and charming coastal city located in the state of Paraná, Brazil, and it boasts a cruise port that offers visitors a unique blend of natural beauty, cultural heritage, and vibrant local life.
Rio de Janeiro, one of the most visited cities in the southern hemisphere, has numerous activities for every desire. Cruise to Rio for the Carnival celebrations, natural environment, beautiful beaches and famous landmarks.
Cruise to Santos for the best of both worlds – a vivacious coastal city that is still quaint and laid back, but with easy access to one of the largest cities in Brazil.
Browse our photo gallery of South America cruising photos from MSC Cruises. Keep in mind, this is just a sample of the sights waiting for you on a MSC Cruises South America cruise vacation.
With an overwhelming world of choices, we understand you may need some personal assistance to plan your perfect vacation. From finding the right destination to choosing the best departure date, we're here to help. Plus, our experienced travel consultants have access to exclusive vacation deals to make sure you get the best value for your time and money.