Holland America Cruises to Panama Canal

Holland America Cruise Experience: Aerial view of their majestic ship transiting the iconic Panama Canal, framed by lush rainforest and mountains under blue sky.

Overview

Dreaming of a vacation that stands out from the rest? Experience a Panama Canal cruise with Holland America Line for a voyage filled with incredible cultural touches, special and memorable experiences, and both natural and man-made excellence. Relax on the serene beaches of the Panamanian coast, or give yourself a thrill filled with natural beauty with a zip line through the rainforest.

Explore intriguing ports-of-call in between, and then gaze in wonder and take a mental picture of the amazing experience that is a trip through the locks. Sound enticing? Join Holland America Line for a cruise to the Panama Canal

Upcoming Holland America Cruises to Panama Canal

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41 Results

Taxes and fees included in all prices shown

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A wide-angle landscape shot of the three iconic volcanoes, Agua, Fuego, and Acatenango, in Guatemala, rising above the clouds during a vibrant sunrise, a scenic view near Puerto Quetzal.

21-night Panama Canal Cruise From Vancouver, British Columbia

Aboard

Nieuw Amsterdam

From

Vancouver, British Columbia

1 Sailing

Sep 27, 2026

1 Sailing

Sep 27, 2026

Published prices from

$2,549

per person*

taxes & fees included

A serene hiking path winds through a dense, lush green jungle with a towering tree on the left, capturing the essence of an adventure in nature.

16-night Panama Canal Cruise From San Diego, California

Aboard

Nieuw Amsterdam

From

San Diego, California

1 Sailing

Oct 2, 2026

1 Sailing

Oct 2, 2026

Published prices from

$2,029

per person*

taxes & fees included

Puntarenas, Costa Rica tropical landscape with palm trees and mountains.

21-night Panama Canal Cruise From Seattle, Washington

Aboard

Eurodam

From

Seattle, Washington

2 Sailings

Oct 3, 2026 - Oct 2, 2027

2 Sailings

Oct 3, 2026 - Oct 2, 2027

Published prices from

$2,649

per person*

taxes & fees included

An aerial view of the bustling city of Balboa, Panama, with a scenic coastal road alongside a marina and tall modern skyscrapers in the background.

20-night Panama Canal Cruise From Vancouver, British Columbia

Aboard

Eurodam

From

Vancouver, British Columbia

2 Sailings

Oct 4, 2026 - Oct 3, 2027

2 Sailings

Oct 4, 2026 - Oct 3, 2027

Published prices from

$2,479

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

16-night Panama Canal Cruise From San Diego, California

Aboard

Eurodam

From

San Diego, California

2 Sailings

Oct 8, 2026 - Oct 7, 2027

2 Sailings

Oct 8, 2026 - Oct 7, 2027

Published prices from

$2,199

per person*

taxes & fees included

21-night Panama Canal & Southern Caribbean Cruise: Abc Islands From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

3 Sailings

Oct 18, 2026 - Mar 21, 2027

3 Sailings

Oct 18, 2026 - Mar 21, 2027

Published prices from

$2,149

per person*

taxes & fees included

A serene aerial shot of Gatun Lake in Panama, featuring a large body of water surrounded by lush, green, forested islands and distant hills under a partly cloudy blue sky.

12-night Panama Canal Discovery Cruise: Costa Rica & Greater Antilles From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

6 Sailings

Oct 18, 2026 - Mar 21, 2027

6 Sailings

Oct 18, 2026 - Mar 21, 2027

Published prices from

$1,379

per person*

taxes & fees included

A sunny view of the colorful waterfront of Willemstad, Curacao, with its iconic pastel-colored Dutch colonial buildings lining the Handelskade street and a ship docked in the port.

21-night Southern Caribbean & Panama Canal: Abc Islands Cruise From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Oct 30, 2026

1 Sailing

Oct 30, 2026

Published prices from

$2,229

per person*

taxes & fees included

Casa Rosada government building in Buenos Aires.

31-night Panama Canal, Inca & South America: Chilean Fjords Cruise From Fort Lauderdale, Florida

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Nov 18, 2026

1 Sailing

Nov 18, 2026

Published prices from

$5,094

per person*

taxes & fees included

A large flock of Guanay cormorants perched on the wooden posts of a pier at General San Martin Port in Peru, with the turquoise ocean and a control tower in the background.

16-night Inca & Panama Canal Discovery: Lima Overnight Cruise From Fort Lauderdale, Florida

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Nov 18, 2026

1 Sailing

Nov 18, 2026

Published prices from

$2,389

per person*

taxes & fees included

15-night Panama Canal Holiday Cruise From San Diego, California

Aboard

Zaandam

From

San Diego, California

2 Sailings

Dec 19, 2026 - Dec 18, 2027

2 Sailings

Dec 19, 2026 - Dec 18, 2027

Published prices from

$2,249

per person*

taxes & fees included

A panoramic shot of the colorful waterfront houses and palm trees of Key West, Florida, reflecting on the calm, turquoise water under a clear blue sky.

19-night Panama Canal Holiday Cruise: Amber Cove & Costa Rica From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 20, 2026

1 Sailing

Dec 20, 2026

Published prices from

$2,389

per person*

taxes & fees included

Immaculate Conception Cathedral in Colon.

12-night Panama Canal Holiday Cruise: Costa Rica & Greater Antilles From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 27, 2026

1 Sailing

Dec 27, 2026

Published prices from

$1,629

per person*

taxes & fees included

21-night Panama Canal & Southern Caribbean Holiday Cruise From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Dec 27, 2026 - Feb 7, 2027

2 Sailings

Dec 27, 2026 - Feb 7, 2027

Published prices from

$2,594

per person*

taxes & fees included

A golden sunset over the beach in Huatulco, Mexico, with footprints in the sand leading towards the shimmering ocean and a warm glow over the water.

14-night Panama Canal Cruise From Miami, Florida

Aboard

Zuiderdam

From

Miami, Florida

1 Sailing

Jan 2, 2027

1 Sailing

Jan 2, 2027

Published prices from

$1,859

per person*

taxes & fees included

Modern building illuminated at sunset along the coast in Callao, Peru.

41-night Grand South America & Antarctica Voyage From Fort Lauderdale, Florida

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Zaandam

From

Fort Lauderdale, Florida

1 Sailing

Jan 3, 2027

1 Sailing

Jan 3, 2027

Published prices from

$10,284

per person*

taxes & fees included

70-night Grand South America & Antarctica Voyage From Fort Lauderdale, Florida

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Zaandam

From

Fort Lauderdale, Florida

1 Sailing

Jan 3, 2027

1 Sailing

Jan 3, 2027

Published prices from

$15,614

per person*

taxes & fees included

A panoramic view of Savusavu, Vanua Levu, Fiji, with a tranquil bay filled with sailboats, a lush green peninsula in the foreground, and mountainous terrain in the background.

35-night Grand World Voyage From Fort Lauderdale, Florida

Aboard

Volendam

From

Fort Lauderdale, Florida

1 Sailing

Jan 5, 2027

1 Sailing

Jan 5, 2027

Published prices from

$8,664

per person*

taxes & fees included

129-night Grand World Voyage Cruise From Fort Lauderdale, Florida

Aboard

Volendam

From

Fort Lauderdale, Florida

1 Sailing

Jan 5, 2027

1 Sailing

Jan 5, 2027

Published prices from

$29,119

per person*

taxes & fees included

21-night Southern Caribbean & Panama Canal Cruise: Abc Islands From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 8 - Feb 19, 2027

2 Sailings

Jan 8 - Feb 19, 2027

Published prices from

$2,734

per person*

taxes & fees included

A wide-angle view of the bustling harbor of Charlotte Amalie, St. Thomas, with many sailboats and yachts docked in the tranquil blue water, and the town's buildings climbing the lush green hills.

21-night Panama Canal & Eastern Caribbean Cruise: U.S. Virgin Islands From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 17 - Feb 28, 2027

2 Sailings

Jan 17 - Feb 28, 2027

Published prices from

$2,729

per person*

taxes & fees included

21-night Eastern Caribbean & Panama Canal Cruise: U.S. Virgin Islands From Fort Lauderdale, Florida

Ft. Lauderdale

St. John's

St. Thomas (Charlotte Amalie)

Roadtown

San Juan

+10 more

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 29 - Mar 12, 2027

2 Sailings

Jan 29 - Mar 12, 2027

Published prices from

$2,719

per person*

taxes & fees included

15-night Panama Canal Cruise From San Diego, California

Aboard

Zuiderdam

From

San Diego, California

1 Sailing

Jan 30, 2027

1 Sailing

Jan 30, 2027

Published prices from

$1,999

per person*

taxes & fees included

31-night Panama Canal, Inca & South America: Chilean Fjords Cruise From Buenos Aires, Argentina

Aboard

Oosterdam

From

Buenos Aires, Argentina

1 Sailing

Mar 9, 2027

1 Sailing

Mar 9, 2027

Published prices from

$4,979

per person*

taxes & fees included

14-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Zaandam

From

Fort Lauderdale, Florida

2 Sailings

Mar 14, 2027 - Jan 16, 2028

2 Sailings

Mar 14, 2027 - Jan 16, 2028

Published prices from

$1,959

per person*

taxes & fees included

A scenic panorama of the coastal city of Manta, Ecuador, with a densely packed urban area surrounded by lush green hills under a dramatic cloudy sky.

16-night Inca & Panama Canal Discovery: Lima Overnight Cruise From San Antonio, Santiago, Chile

Santiago (San Antonio)

Aboard

Oosterdam

From

San Antonio, Santiago, Chile

1 Sailing

Mar 24, 2027

1 Sailing

Mar 24, 2027

Published prices from

$2,539

per person*

taxes & fees included

Golden Gate Bridge and San Francisco Bay.

21-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$2,639

per person*

taxes & fees included

20-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$2,534

per person*

taxes & fees included

14-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$1,894

per person*

taxes & fees included

A scenic sunset over the iconic rock formations of Land's End, including El Arco, a major landmark of Cabo San Lucas, Mexico.

21-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 11, 2027

1 Sailing

Apr 11, 2027

Published prices from

$2,439

per person*

taxes & fees included

17-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 11, 2027

1 Sailing

Apr 11, 2027

Published prices from

$2,079

per person*

taxes & fees included

23-night Caribbean Holiday & Panama Canal Discovery Cruise From Fort Lauderdale, Florida

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 22, 2027

1 Sailing

Dec 22, 2027

Published prices from

$4,244

per person*

taxes & fees included

21-night Panama Canal & Southern Caribbean: Abc Islands Cruise From Fort Lauderdale, Florida

Aboard

Oosterdam

From

Fort Lauderdale, Florida

4 Sailings

Jan 2 - Mar 5, 2028

4 Sailings

Jan 2 - Mar 5, 2028

Published prices from

$3,459

per person*

taxes & fees included

12-night Panama Canal Discovery: Costa Rica & Greater Antilles Cruise From Fort Lauderdale, Florida

Aboard

Oosterdam

From

Fort Lauderdale, Florida

5 Sailings

Jan 2 - Mar 26, 2028

5 Sailings

Jan 2 - Mar 26, 2028

Published prices from

$2,119

per person*

taxes & fees included

21-night Southern Caribbean & Panama Canal: Abc Islands Cruise From Fort Lauderdale, Florida

Aboard

Oosterdam

From

Fort Lauderdale, Florida

4 Sailings

Jan 14 - Mar 17, 2028

4 Sailings

Jan 14 - Mar 17, 2028

Published prices from

$3,549

per person*

taxes & fees included

A pelican standing on a wooden pier in Coquimbo, Chile, with numerous yellow fishing boats floating in the background and mountains visible across the bay.

32-night Panama Canal, Inca & South America: Chilean Fjords Cruise From Buenos Aires, Argentina

Aboard

Nieuw Amsterdam

From

Buenos Aires, Argentina

1 Sailing

Mar 6, 2028

1 Sailing

Mar 6, 2028

Published prices from

$5,289

per person*

taxes & fees included

17-night Inca & Panama Canal Discovery: Lima Overnight Cruise From San Antonio, Santiago, Chile

Santiago (San Antonio)

Aboard

Nieuw Amsterdam

From

San Antonio, Santiago, Chile

1 Sailing

Mar 21, 2028

1 Sailing

Mar 21, 2028

Published prices from

$2,879

per person*

taxes & fees included

A statue of Jesus stands on a rocky islet in the Pacific Ocean, with waves crashing around it near the port of Acajutla, El Salvador.

16-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 1, 2028

1 Sailing

Apr 1, 2028

Published prices from

$2,944

per person*

taxes & fees included

22-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 1, 2028

1 Sailing

Apr 1, 2028

Published prices from

$3,519

per person*

taxes & fees included

21-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 7, 2028

1 Sailing

Apr 7, 2028

Published prices from

$3,539

per person*

taxes & fees included

Yellow kayak on sandy beach in Puerto Vallarta, Mexico.

15-night Panama Canal Cruise From Fort Lauderdale, Florida

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 7, 2028

1 Sailing

Apr 7, 2028

Published prices from

$2,854

per person*

taxes & fees included

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.