Holland America Cruises to Panama Canal

Holland America Cruise Experience: Aerial view of their majestic ship transiting the iconic Panama Canal, framed by lush rainforest and mountains under blue sky.

Overview

Dreaming of a vacation that stands out from the rest? Experience a Panama Canal cruise with Holland America Line for a voyage filled with incredible cultural touches, special and memorable experiences, and both natural and man-made excellence. Relax on the serene beaches of the Panamanian coast, or give yourself a thrill filled with natural beauty with a zip line through the rainforest.

Explore intriguing ports-of-call in between, and then gaze in wonder and take a mental picture of the amazing experience that is a trip through the locks. Sound enticing? Join Holland America Line for a cruise to the Panama Canal

Upcoming Holland America Cruises to Panama Canal

Filter

41 Results

Taxes and fees included in all prices shown

Sort

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

21-night Panama Canal Cruise

Aboard

Nieuw Amsterdam

From

Vancouver, British Columbia

1 Sailing

Sep 27, 2026

1 Sailing

Sep 27, 2026

Published prices from

$2,104

per person*

taxes & fees included

A secluded cove with white sand and turquoise water on Half Moon Cay, Bahamas, surrounded by jagged, rocky cliffs and a serene blue ocean under a partly cloudy sky.

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

16-night Panama Canal Cruise

Aboard

Nieuw Amsterdam

From

San Diego, California

1 Sailing

Oct 2, 2026

1 Sailing

Oct 2, 2026

Published prices from

$1,609

per person*

taxes & fees included

A cruise ship navigating through the Gatun Locks of the Panama Canal, an important navigational route and popular tourist destination.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal Cruise

Aboard

Eurodam

From

Seattle, Washington

2 Sailings

Oct 3, 2026 - Oct 2, 2027

2 Sailings

Oct 3, 2026 - Oct 2, 2027

Published prices from

$2,204

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

20-night Panama Canal Cruise

Aboard

Eurodam

From

Vancouver, British Columbia

2 Sailings

Oct 4, 2026 - Oct 3, 2027

2 Sailings

Oct 4, 2026 - Oct 3, 2027

Published prices from

$2,239

per person*

taxes & fees included

A serene hiking path winds through a dense, lush green jungle with a towering tree on the left, capturing the essence of an adventure in nature.

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

16-night Panama Canal Cruise

Aboard

Eurodam

From

San Diego, California

2 Sailings

Oct 8, 2026 - Oct 7, 2027

2 Sailings

Oct 8, 2026 - Oct 7, 2027

Published prices from

$1,779

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

12-night Panama Canal Discovery Cruise: Costa Rica & Greater Antilles

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

6 Sailings

Oct 18, 2026 - Mar 21, 2027

6 Sailings

Oct 18, 2026 - Mar 21, 2027

Published prices from

$1,209

per person*

taxes & fees included

A scenic shot of the stunning Seven Mile Beach in Grand Cayman, with a wide, sandy beach, calm turquoise water, and resorts with palm trees under a beautiful blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal & Southern Caribbean Cruise: Abc Islands

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

3 Sailings

Oct 18, 2026 - Mar 21, 2027

3 Sailings

Oct 18, 2026 - Mar 21, 2027

Published prices from

$1,899

per person*

taxes & fees included

A serene aerial shot of Gatun Lake in Panama, featuring a large body of water surrounded by lush, green, forested islands and distant hills under a partly cloudy blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Southern Caribbean & Panama Canal: Abc Islands Cruise

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Oct 30, 2026

1 Sailing

Oct 30, 2026

Published prices from

$1,929

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

31-night Panama Canal, Inca & South America: Chilean Fjords Cruise

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Nov 18, 2026

1 Sailing

Nov 18, 2026

Published prices from

$4,534

per person*

taxes & fees included

Modern building illuminated at sunset along the coast in Callao, Peru.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

16-night Inca & Panama Canal Discovery: Lima Overnight Cruise

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Nov 18, 2026

1 Sailing

Nov 18, 2026

Published prices from

$2,179

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

15-night Panama Canal Holiday Cruise

Aboard

Zaandam

From

San Diego, California

2 Sailings

Dec 19, 2026 - Dec 18, 2027

2 Sailings

Dec 19, 2026 - Dec 18, 2027

Published prices from

$1,974

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

19-night Panama Canal Holiday Cruise: Amber Cove & Costa Rica

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 20, 2026

1 Sailing

Dec 20, 2026

Published prices from

$2,339

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal & Southern Caribbean Holiday Cruise

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Dec 27, 2026 - Feb 7, 2027

2 Sailings

Dec 27, 2026 - Feb 7, 2027

Published prices from

$2,384

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

12-night Panama Canal Holiday Cruise: Costa Rica & Greater Antilles

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 27, 2026

1 Sailing

Dec 27, 2026

Published prices from

$1,559

per person*

taxes & fees included

An aerial view of the bustling city of Balboa, Panama, with a scenic coastal road alongside a marina and tall modern skyscrapers in the background.

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

14-night Panama Canal Cruise

Aboard

Zuiderdam

From

Miami, Florida

1 Sailing

Jan 2, 2027

1 Sailing

Jan 2, 2027

Published prices from

$1,669

per person*

taxes & fees included

A breathtaking view of the massive Pio XI Glacier in Chile, showing its bright blue ice arching over the water, with a rocky shoreline and mountains in the distance under a blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

41-night Grand South America & Antarctica Voyage

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Zaandam

From

Fort Lauderdale, Florida

1 Sailing

Jan 3, 2027

1 Sailing

Jan 3, 2027

Published prices from

$10,284

per person*

taxes & fees included

A scenic aerial shot of the tropical Morro de Sao Paulo beach in Brazil, showing the turquoise Atlantic Ocean, a long stretch of golden sand, and a village with red-roofed houses nestled against a lush green hill.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

70-night Grand South America & Antarctica Voyage

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Zaandam

From

Fort Lauderdale, Florida

1 Sailing

Jan 3, 2027

1 Sailing

Jan 3, 2027

Published prices from

$15,614

per person*

taxes & fees included

Sydney Opera House and city skyline at sunset.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

35-night Grand World Voyage

Aboard

Volendam

From

Fort Lauderdale, Florida

1 Sailing

Jan 5, 2027

1 Sailing

Jan 5, 2027

Published prices from

$8,664

per person*

taxes & fees included

An aerial view of the bustling city of Surabaya, Indonesia, showing a dense collection of buildings with distinctive red-tiled roofs and scattered green spaces.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

129-night Grand World Voyage Cruise

Aboard

Volendam

From

Fort Lauderdale, Florida

1 Sailing

Jan 5, 2027

1 Sailing

Jan 5, 2027

Published prices from

$29,119

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Southern Caribbean & Panama Canal Cruise: Abc Islands

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 8 - Feb 19, 2027

2 Sailings

Jan 8 - Feb 19, 2027

Published prices from

$2,384

per person*

taxes & fees included

An aerial view of the colorful waterfront of St. John's, Antigua, with a long pier extending into the calm, blue sea and the town's charming buildings and marina in the background.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal & Eastern Caribbean Cruise: U.S. Virgin Islands

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 17 - Feb 28, 2027

2 Sailings

Jan 17 - Feb 28, 2027

Published prices from

$2,389

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Eastern Caribbean & Panama Canal Cruise: U.S. Virgin Islands

Ft. Lauderdale

St. John's

St. Thomas (Charlotte Amalie)

Roadtown

San Juan

+10 more

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

2 Sailings

Jan 29 - Mar 12, 2027

2 Sailings

Jan 29 - Mar 12, 2027

Published prices from

$2,379

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 1 more offer

TCW EXCLUSIVE

15-night Panama Canal Cruise

Aboard

Zuiderdam

From

San Diego, California

1 Sailing

Jan 30, 2027

1 Sailing

Jan 30, 2027

Published prices from

$1,774

per person*

taxes & fees included

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

31-night Panama Canal, Inca & South America: Chilean Fjords Cruise

Aboard

Oosterdam

From

Buenos Aires, Argentina

1 Sailing

Mar 9, 2027

1 Sailing

Mar 9, 2027

Published prices from

$4,669

per person*

taxes & fees included

A golden sunset over the beach in Huatulco, Mexico, with footprints in the sand leading towards the shimmering ocean and a warm glow over the water.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

14-night Panama Canal Cruise

Aboard

Zaandam

From

Fort Lauderdale, Florida

2 Sailings

Mar 14, 2027 - Jan 16, 2028

2 Sailings

Mar 14, 2027 - Jan 16, 2028

Published prices from

$1,769

per person*

taxes & fees included

A blue, rustic fishing boat floats in the turquoise and clear water of a tropical beach near Trujillo, Peru, with a small, green island in the distance.

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

16-night Inca & Panama Canal Discovery: Lima Overnight Cruise

Santiago (San Antonio)

Aboard

Oosterdam

From

San Antonio, Santiago, Chile

1 Sailing

Mar 24, 2027

1 Sailing

Mar 24, 2027

Published prices from

$2,379

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

20-night Panama Canal Cruise

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$2,304

per person*

taxes & fees included

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

14-night Panama Canal Cruise

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$1,694

per person*

taxes & fees included

Golden Gate Bridge and San Francisco Bay.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal Cruise

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 3, 2027

1 Sailing

Apr 3, 2027

Published prices from

$2,404

per person*

taxes & fees included

Yellow kayak on sandy beach in Puerto Vallarta, Mexico.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

21-night Panama Canal Cruise

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 11, 2027

1 Sailing

Apr 11, 2027

Published prices from

$2,154

per person*

taxes & fees included

A beautiful beach in Acapulco, Mexico, with thatched-roof umbrellas on the golden sand, facing the turquoise ocean under a clear blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

TCW EXCLUSIVE

17-night Panama Canal Cruise

Aboard

Nieuw Amsterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 11, 2027

1 Sailing

Apr 11, 2027

Published prices from

$1,809

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.

23-night Caribbean Holiday & Panama Canal Discovery Cruise

Ft. Lauderdale

Grand Cayman (George Town)

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Dec 22, 2027

1 Sailing

Dec 22, 2027

Published prices from

$6,876

per person*

taxes & fees included

21-night Panama Canal & Southern Caribbean: Abc Islands Cruise

Aboard

Oosterdam

From

Fort Lauderdale, Florida

4 Sailings

Jan 2 - Mar 5, 2028

4 Sailings

Jan 2 - Mar 5, 2028

Published prices from

$5,437

per person*

taxes & fees included

Immaculate Conception Cathedral in Colon.

12-night Panama Canal Discovery: Costa Rica & Greater Antilles Cruise

Aboard

Oosterdam

From

Fort Lauderdale, Florida

5 Sailings

Jan 2 - Mar 26, 2028

5 Sailings

Jan 2 - Mar 26, 2028

Published prices from

$3,323

per person*

taxes & fees included

21-night Southern Caribbean & Panama Canal: Abc Islands Cruise

Aboard

Oosterdam

From

Fort Lauderdale, Florida

4 Sailings

Jan 14 - Mar 17, 2028

4 Sailings

Jan 14 - Mar 17, 2028

Published prices from

$5,531

per person*

taxes & fees included

A massive, stunning blue and white glacier in the Sarmiento Channel, Patagonia, Chile, with its dramatic crevasses and ice formations towering over the deep blue water.

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

32-night Panama Canal, Inca & South America: Chilean Fjords Cruise

Aboard

Nieuw Amsterdam

From

Buenos Aires, Argentina

1 Sailing

Mar 6, 2028

1 Sailing

Mar 6, 2028

Published prices from

$5,289

per person*

taxes & fees included

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

17-night Inca & Panama Canal Discovery: Lima Overnight Cruise

Santiago (San Antonio)

Aboard

Nieuw Amsterdam

From

San Antonio, Santiago, Chile

1 Sailing

Mar 21, 2028

1 Sailing

Mar 21, 2028

Published prices from

$2,879

per person*

taxes & fees included

A scenic sunset over the iconic rock formations of Land's End, including El Arco, a major landmark of Cabo San Lucas, Mexico.

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

16-night Panama Canal Cruise

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 1, 2028

1 Sailing

Apr 1, 2028

Published prices from

$2,944

per person*

taxes & fees included

A serene sunset view of a beautiful sandy beach in Santa Barbara, California, with a row of iconic palm trees and the coastal cityscape with mountains in the background.

Exclusive Onboard Savings, Events & Reduced Fares with Mariner Society*

22-night Panama Canal Cruise

Aboard

Eurodam

From

Fort Lauderdale, Florida

1 Sailing

Apr 1, 2028

1 Sailing

Apr 1, 2028

Published prices from

$3,519

per person*

taxes & fees included

21-night Panama Canal Cruise

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 7, 2028

1 Sailing

Apr 7, 2028

Published prices from

$5,519

per person*

taxes & fees included

15-night Panama Canal Cruise

Aboard

Oosterdam

From

Fort Lauderdale, Florida

1 Sailing

Apr 7, 2028

1 Sailing

Apr 7, 2028

Published prices from

$4,610

per person*

taxes & fees included

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.