Royal Caribbean Cruises from Colon, Panama

Immaculate Conception Cathedral in Colon.

Upcoming Royal Caribbean Cruises from Colon, Panama

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Immaculate Conception Cathedral in Colon.

FREE Dining, Onboard Activities & More*+ 1 more offer

7-night Southern Caribbean Cruise

Cartagena (Colombia)

Aboard

Serenade of the Seas

From

Colon, Panama

16 Sailings

Nov 29, 2025 - Apr 11, 2026

16 Sailings

Nov 29, 2025 - Apr 11, 2026

Published prices from

$866

per person*

taxes & fees included

Immaculate Conception Cathedral in Colon.

FREE Dining, Onboard Activities & More*+ 1 more offer

6-night Southern Caribbean Cruise

Cartagena (Colombia)

Aboard

Serenade of the Seas

From

Colon, Panama

1 Sailing

Dec 6, 2025

1 Sailing

Dec 6, 2025

Colorful colonial balconies in Cartagena.

FREE Dining, Onboard Activities & More*+ 1 more offer

8-night Southern Caribbean Cruise

Cartagena (Colombia)

Aboard

Serenade of the Seas

From

Colon, Panama

1 Sailing

Dec 12, 2025

1 Sailing

Dec 12, 2025

Published prices from

$2,289

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

FREE Dining, Onboard Activities & More*+ 1 more offer

7-night Southern Caribbean Holiday Cruise

Cartagena (Colombia)

Aboard

Serenade of the Seas

From

Colon, Panama

2 Sailings

Dec 20 - Dec 27, 2025

2 Sailings

Dec 20 - Dec 27, 2025

Published prices from

$2,623

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.

FREE Dining, Onboard Activities & More*+ 1 more offer

1-night Southern Caribbean Cruise

Cartagena (Colombia)

Aboard

Serenade of the Seas

From

Colon, Panama

1 Sailing

Apr 18, 2026

1 Sailing

Apr 18, 2026

Published prices from

$153

per person*

taxes & fees included

Immaculate Conception Cathedral in Colon.

FREE Dining, Onboard Activities & More*+ 1 more offer

10-night Panama Canal Westward Cruise

Puerto Vallarta

Aboard

Serenade of the Seas

From

Colon, Panama

1 Sailing

Apr 25, 2026

1 Sailing

Apr 25, 2026

Published prices from

$1,247

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

FREE Dining, Onboard Activities & More*+ 1 more offer

7-night Southern Caribbean Cruise

Cartagena (Colombia)

Aboard

Grandeur of the Seas

From

Colon, Panama

43 Sailings

May 9, 2026 - Apr 17, 2027

43 Sailings

May 9, 2026 - Apr 17, 2027

Published prices from

$928

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

FREE Dining, Onboard Activities & More*+ 1 more offer

10-night Southern Caribbean Cruise

Aboard

Grandeur of the Seas

From

Colon, Panama

1 Sailing

Nov 14, 2026

1 Sailing

Nov 14, 2026

Published prices from

$1,419

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

FREE Dining, Onboard Activities & More*+ 1 more offer

7-night Southern Caribbean Holiday Cruise

Cartagena (Colombia)

Aboard

Grandeur of the Seas

From

Colon, Panama

2 Sailings

Dec 19 - Dec 26, 2026

2 Sailings

Dec 19 - Dec 26, 2026

Published prices from

$1,284

per person*

taxes & fees included

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.