MSC Cruises from Palermo, Sicily, Italy

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Upcoming MSC Cruises from Palermo, Sicily, Italy

13 Results

Taxes and fees included in all prices shown

Sort

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Barcelona (Tarragona)

Provence (Marseille)

Florence/Pisa (Livorno)

Aboard

MSC Splendida

From

Palermo, Sicily, Italy

20 Sailings

Jun 25 - Nov 5, 2026

20 Sailings

Jun 25 - Nov 5, 2026

Published prices from

$930

per person*

taxes & fees included

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Meraviglia

From

Palermo, Sicily, Italy

16 Sailings

Jun 26 - Oct 9, 2026

16 Sailings

Jun 26 - Oct 9, 2026

Published prices from

$848

per person*

taxes & fees included

St. Peter's Basilica, Rome cityscape at sunset.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Barcelona (Tarragona)

Provence (Marseille)

Aboard

MSC Seaview

From

Palermo, Sicily, Italy

60 Sailings

Jun 29, 2026 - Jan 6, 2028

60 Sailings

Jun 29, 2026 - Jan 6, 2028

Published prices from

$791

per person*

taxes & fees included

A beautiful image of a narrow, stone-paved street in a medieval Italian village near Livorno, adorned with ivy-covered walls, potted plants, and colorful flowers, giving a feeling of tranquility.

Up to $500 FREE Onboard Credit*+ 2 more offers

4 nights Westmed From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Meraviglia

From

Palermo, Sicily, Italy

1 Sailing

Oct 16, 2026

1 Sailing

Oct 16, 2026

Published prices from

$369

per person*

taxes & fees included

A stunning panoramic view of Alicante, Spain, at sunset, with the historic city nestled at the foot of Mount Benacantil and the Santa Bárbara Castle, with the Mediterranean Sea in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

23 nights Caribbean From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Meraviglia

From

Palermo, Sicily, Italy

1 Sailing

Oct 16, 2026

1 Sailing

Oct 16, 2026

A scenic panoramic shot from the top of the Rock of Gibraltar, overlooking the city, marina, and the Mediterranean Sea under a bright blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

26 nights Caribbean From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Meraviglia

From

Palermo, Sicily, Italy

1 Sailing

Oct 16, 2026

1 Sailing

Oct 16, 2026

Published prices from

$2,558

per person*

taxes & fees included

Roman Amphitheatre of Tarragona by the sea.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Barcelona (Tarragona)

Provence (Marseille)

Aboard

MSC Euribia

From

Palermo, Sicily, Italy

45 Sailings

Oct 28, 2026 - Mar 22, 2028

45 Sailings

Oct 28, 2026 - Mar 22, 2028

Published prices from

$610

per person*

taxes & fees included

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

20 nights South America From Palermo, Sicily, Italy

Barcelona (Tarragona)

Aboard

MSC Splendida

From

Palermo, Sicily, Italy

1 Sailing

Nov 12, 2026

1 Sailing

Nov 12, 2026

Valletta, Malta skyline with illuminated buildings at dusk.

Up to $500 FREE Onboard Credit*+ 2 more offers

21 nights South America From Palermo, Sicily, Italy

Barcelona (Tarragona)

Aboard

MSC Splendida

From

Palermo, Sicily, Italy

1 Sailing

Nov 12, 2026

1 Sailing

Nov 12, 2026

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Provence (Marseille)

Aboard

MSC Musica

From

Palermo, Sicily, Italy

28 Sailings

Apr 19 - Oct 25, 2027

28 Sailings

Apr 19 - Oct 25, 2027

Published prices from

$820

per person*

taxes & fees included

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

7 nights Westmed From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Virtuosa

From

Palermo, Sicily, Italy

29 Sailings

Apr 23 - Nov 5, 2027

29 Sailings

Apr 23 - Nov 5, 2027

Published prices from

$980

per person*

taxes & fees included

A scenic panoramic view of Ilhabela, Brazil, showing a long, sandy beach with turquoise water, a river flowing to the sea, and lush, green mountains under a bright blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

22 nights Westmed From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Virtuosa

From

Palermo, Sicily, Italy

1 Sailing

Nov 12, 2027

1 Sailing

Nov 12, 2027

A high-angle view of the historic city of Palermo, Sicily, with a clear blue sky, buildings and rooftops in the foreground, and mountains in the distance.

Up to $500 FREE Onboard Credit*+ 2 more offers

20 nights Westmed From Palermo, Sicily, Italy

Florence/Pisa (Livorno)

Provence (Marseille)

Barcelona (Tarragona)

Aboard

MSC Virtuosa

From

Palermo, Sicily, Italy

1 Sailing

Nov 12, 2027

1 Sailing

Nov 12, 2027

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.