River U.S. Rivers & Great Lakes Cruises 2025 - Premium Cruise Lines

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.

River U.S. Rivers & Great Lakes Cruises

Upcoming River U.S. Rivers & Great Lakes Cruises

More to Explore

Cruise Deals - delivered to your inbox

7-night Mississippi Delta Explorer Cruise

$4,299

21-night Mississippi River Odyssey Cruise

$14,998

7-night Nashville, Memphis & The Cumberland Cruise

$5,499

14-night America's Great River Cruise

$12,999

14-night The Big Easy To The Gateway City Cruise

$8,999

7-night Nashville, Memphis & The Cumberland Cruise

$4,999

7-night New Orleans & Southern Charms Cruise

$3,499

7-night Heartland Of America Cruise

$5,799

7-night Heartland Of America Cruise

$5,799

7-night Mississippi Delta Explorer Cruise

$4,299

10-night New Orleans To Memphis Cruise

$8,999

River U.S. Rivers & Great Lakes Cruises

Upcoming River U.S. Rivers & Great Lakes Cruises

More to Explore

Destinations

Departure Ports

Cruise Lines

Deals

Land Vacations

All About Cruising

7-night Mississippi Delta Explorer Cruise

$4,299

21-night Mississippi River Odyssey Cruise

$14,998

7-night Nashville, Memphis & The Cumberland Cruise

$5,499

14-night America's Great River Cruise

$12,999

14-night The Big Easy To The Gateway City Cruise

$8,999

7-night Nashville, Memphis & The Cumberland Cruise

$4,999

7-night New Orleans & Southern Charms Cruise

$3,499

7-night Heartland Of America Cruise

$5,799

7-night Heartland Of America Cruise

$5,799

7-night Mississippi Delta Explorer Cruise

$4,299

10-night New Orleans To Memphis Cruise

$8,999