Panama City, Panama Cruise Deals

Modern Panama City skyline with skyscrapers.

Upcoming Panama City, Panama Cruise Deals

12 Results

Taxes and fees included in all prices shown

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Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

Up to $500 FREE Onboard Credit*+ 2 more offers

Oceania Cruises

10-night Classic Canal & Tropics Voyage

Cartagena (Colombia)

Aboard

Insignia

From

Panama City, Panama

1 Sailing

Apr 4, 2026

1 Sailing

Apr 4, 2026

Published prices from

$2,760

per person*

taxes & fees included

Tropical beach with lounge chairs in Cozumel.

Up to $500 FREE Onboard Credit*+ 2 more offers

Oceania Cruises

10-night Canal & Coral Isles Voyage

Cartagena (Colombia)

Aboard

Insignia

From

Panama City, Panama

1 Sailing

Apr 24, 2026

1 Sailing

Apr 24, 2026

Published prices from

$3,399

per person*

taxes & fees included

An elevated panoramic shot of the beautiful Ocho Rios Bay in Jamaica, showing a large cruise ship docked at the pier, a sandy beach, and luxury resorts under a blue sky.

Up to $500 FREE Onboard Credit*+ 2 more offers

Oceania Cruises

10-night Panama To Caribbean Joy Voyage

Cartagena (Colombia)

Aboard

Marina

From

Panama City, Panama

1 Sailing

Jan 15, 2027

1 Sailing

Jan 15, 2027

Published prices from

$3,049

per person*

taxes & fees included

Hollywood sign on hills of Los Angeles.

Up to $500 FREE Onboard Credit*+ 2 more offers

28-night Canal To Coral Reefs Cruise

Puerto Vallarta

Aboard

Seven Seas Splendor

From

Panama City, Panama

1 Sailing

Jan 26, 2027

1 Sailing

Jan 26, 2027

Published prices from

$21,399

per person*

taxes & fees included

A close-up of vibrant, traditional Mayan textiles from Santo Tomás de Castilla, Guatemala, featuring intricate, colorful hand-embroidered floral patterns on a dark fabric.

Up to $500 FREE Onboard Credit*+ 2 more offers

11-night Crescent Beaches & Colorful Towns Cruise

Aboard

Seven Seas Prestige

From

Panama City, Panama

1 Sailing

Feb 22, 2027

1 Sailing

Feb 22, 2027

Published prices from

$8,999

per person*

taxes & fees included

An aerial view of the vast Amazon River in Peru, meandering through a dense, green rainforest with a small floating lodge anchored along its banks.

Up to $500 FREE Onboard Credit*+ 2 more offers

22-night Journey To The Amazon Cruise

Aboard

Seven Seas Grandeur

From

Panama City, Panama

1 Sailing

Mar 9, 2027

1 Sailing

Mar 9, 2027

Published prices from

$17,149

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.

Up to $500 FREE Onboard Credit*+ 2 more offers

Oceania Cruises

10-night Panama & Pristine Isles Voyage

Cartagena (Colombia)

Aboard

Marina

From

Panama City, Panama

1 Sailing

Mar 15, 2027

1 Sailing

Mar 15, 2027

Published prices from

$3,099

per person*

taxes & fees included

Modern Panama City skyline with skyscrapers.

Up to $500 FREE Onboard Credit*+ 2 more offers

14-night Carnival Of Caribbean Colors Cruise

Cartagena (Colombia)

Aboard

Seven Seas Grandeur

From

Panama City, Panama

1 Sailing

Mar 31, 2027

1 Sailing

Mar 31, 2027

Published prices from

$9,449

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.

Up to $500 FREE Onboard Credit*+ 1 more offer

Oceania Cruises

10-night Classic Canal & Tropics Voyage

Cartagena (Colombia)

Aboard

Marina

From

Panama City, Panama

1 Sailing

Jan 16, 2028

1 Sailing

Jan 16, 2028

Published prices from

$3,099

per person*

taxes & fees included

Colorful colonial balconies in Cartagena.

Up to $500 FREE Onboard Credit*+ 1 more offer

26-night Azure To Iberia Cruise

Cartagena (Colombia)

Aboard

Seven Seas Prestige

From

Panama City, Panama

1 Sailing

Mar 14, 2028

1 Sailing

Mar 14, 2028

Published prices from

$17,049

per person*

taxes & fees included

Oranjestad, Aruba harbor with boats and colorful Dutch architecture.

Up to $500 FREE Onboard Credit*+ 1 more offer

12-night Bon Bini Aruba Cruise

Cartagena (Colombia)

Aboard

Seven Seas Prestige

From

Panama City, Panama

1 Sailing

Mar 14, 2028

1 Sailing

Mar 14, 2028

Published prices from

$8,599

per person*

taxes & fees included

A close-up of vibrant, traditional Mayan textiles from Santo Tomás de Castilla, Guatemala, featuring intricate, colorful hand-embroidered floral patterns on a dark fabric.

Up to $500 FREE Onboard Credit*+ 1 more offer

Oceania Cruises

10-night Spanich Lullaby Voyage

Santo Tomas de Castilla

Aboard

Marina

From

Panama City, Panama

1 Sailing

Mar 15, 2028

1 Sailing

Mar 15, 2028

Published prices from

$2,999

per person*

taxes & fees included

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.