7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise And 3-nights In Panama City Post Cruise Cruise/Land Package From Medellín, Colombia

AmaWaterways' Logo.

A beautiful colonial-era church in Mompox, Colombia, with its vibrant yellow facade, ornate bell tower, and bright red dome standing out against a clear blue sky.
Amawaterways AmaMelodia river ship exterior.
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Sailing Jul 24, 2026 - Jun 11, 2027

from $7,874 per person* taxes and fees included

Your 15-night South America Cruise at a Glance

Sailings aboard AmaMelodia depart from Medellín, Colombia with 10 stops in ports-of-call including Cartagena (Colombia), Gambote (Palenque), and El Banco. The Cruise Web can help you find the best deals and stateroom prices on any of the 19 upcoming sailings in 2026 and 2027.

Departure Port

Medellín, Colombia

Medellín is a dynamic, hillside city that’s transformed itself into one of South America’s most innovative and inviting urban centers. Before you depart Medellín, Colombia, we can help you plan travel and accommodations for your South America cruise.

Destination

South America

Stops on your South America voyage will include Cartagena (Colombia) on day 4 and Magangue on day 11. We can help you with excursions and making the most of any itinerary.

Cruise Ship

AmaMelodia

AmaMelodia, built in 2024, carries 64 passengers with a crew of 30.

Cruise Line

AmaWaterways

Explore the world’s most beautiful rivers, creating a lifetime of memories from AmaWaterways’ intimate, luxurious river ships. We can help you maximize deals on South America cruises aboard AmaMelodia or 33 of AmaWaterways’s other ships.